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FLASH GENE
Symbol CRKL contributors: mct/npt/pgu - updated : 25-09-2013
HGNC name v-crk sarcoma virus CT10 oncogene homolog (avian)-like
HGNC id 2363
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification --over  
contribute to diverse oncogenic phenotypes in lung cancer, with implications for targeted therapy, and highlight a role of adapter proteins as primary genetic drivers of tumorigenesis
tumoral     --over  
correlated with progression and malignant proliferation of breast cancers
constitutional     --other  
haploinsufficiency of CRKL could be responsible for the etiology of conotruncal heart defects (CTDs) in individuals with nested distal deletions and might act as a genetic modifier of individuals with the typical 3 Mb deletion
Susceptibility
Variant & Polymorphism
Candidate gene DEL22Q11
Marker
  • may be a potential molecular target for head and neck squamous cell carcinoma (HNSCC) diagnosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    novel therapeutic strategies as well as CRK
    cancerdigestivestomach
    has the potential to serve as a molecular therapy target for gastric cancer
    ANIMAL & CELL MODELS
    mice homozygous for a null mutation exhibit defectsin multiplecranial and cardiac neural crestderivatives, similar to the clinical manifestations of DG/VCFS