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FLASH GENE
Symbol IBSP contributors: mct - updated : 13-10-2014
HGNC name integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
HGNC id 5341
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
during early bone formation and may play a role in primary mineralization of bone
constitutional     --low  
affects both osteoclast formation and activity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption