Symbol
| LACC1
| contributors: mct - updated : 06-06-2018
|
HGNC name
| laccase domain containing 1
|
HGNC id
| 26789
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
| germinal mutation
|  
|  
|  
|
in juvenile idiopathic arthritis (JIA) | |
Susceptibility
|
to leprosy to systemic juvenile idiopathic arthritis, and Crohn disease |
Variant & Polymorphism
SNP
| association between missense variant rs3764147 (c.760A>G [p.Ile254Val]) in the GWAS hit LACC1 (formerly C13orf31) and leprosy |
|
single-nucleotide variations that encode p.C284R and p.I254V are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn disease |
Candidate gene
Marker
Therapy target
| | | |