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FLASH GENE
Symbol LACC1 contributors: mct - updated : 06-06-2018
HGNC name laccase domain containing 1
HGNC id 26789
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
in juvenile idiopathic arthritis (JIA)
Susceptibility
  • to leprosy
  • to systemic juvenile idiopathic arthritis, and Crohn disease
  • Variant & Polymorphism SNP
  • association between missense variant rs3764147 (c.760A>G [p.Ile254Val]) in the GWAS hit LACC1 (formerly C13orf31) and leprosy
  • single-nucleotide variations that encode p.C284R and p.I254V are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS