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FLASH GENE
Symbol CDC25B contributors: mct/npt/pgu - updated : 09-01-2016
HGNC name cell division cycle 25 homolog B (S. pombe)
HGNC id 1726
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
caused an earlier centrosome splitting in late G2
tumoral     --over  
in a significant number of cancers, including colon carcinoma, and often associated with high grade tumours and poor prognosis
constitutional     --low  
results in a specific lengthening of the G2 phase, whereas the S-phase length and the total cell cycle time are not significantly modified
tumoral     --over  
is commonly found in human cancer, results in a significant increase in centrin 2 at the centrosomes of interphase cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
expression level of CDC25B might be a potential key parameter of the cellular response to cancer therapy
ANIMAL & CELL MODELS
  • Cdc25b-deficient mice