Symbol
| NABP2
| contributors: mct/pgu - updated : 15-04-2017
|
HGNC name
| nucleic acid binding protein 2
|
HGNC id
| 28412
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
|  
| loss of function
|
leading to increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair | |
Candidate gene
Marker
Therapy target
| | | |
| loss of Obfc2b in mice results in perinatal lethality characterized by growth delay and skeletal abnormalities | |
germline Ssb1(-/-) embryos die at birth from respiratory failure due to severe rib cage malformation and impaired alveolar development, coupled with additional skeletal defects |