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FLASH GENE
Symbol C1QTNF12 contributors: mct - updated : 20-02-2018
HGNC name C1q and TNF related 12
HGNC id 32308
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabete  
new target molecule for the treatment of insulin resistance and diabetes
ANIMAL & CELL MODELS
  • increasing adipolin expression ameliorates adipose tissue inflammation and promotes glucose clearance in obese mice
  • diet-induced obese (DIO) mice showed a significant reduction of plasma levels of full and total (full and cleaved) adipolin compared with control mice, resulting in an increase in the ratio of cleaved to full isoform
  • in mice, loss of a single Ctrp12 allele affects glucose and lipid metabolism in a sex-dependent manner