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FLASH GENE
Symbol SOCS7 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 7
HGNC id 29846
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in Alzheimer disease brains
tumoral     --over  
significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
Susceptibility to obesity, disturbances in lipid metabolism and insulin resistance
Variant & Polymorphism other associations between SOCS7 common variants and related haplotypes and obesity, Insulin resistance and lipid metabolism disorders
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Socs7 deficient mice develop islet hyperplasia in the setting of increased insulin sensitivity and normal glucose tolerance
  • lack of Socs7 is associated with severe skin disease in mice