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FLASH GENE
Symbol FBLN2 contributors: mct - updated : 05-12-2012
HGNC name fibulin 2
HGNC id 3601
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in several breast cancer cell lines
constitutional        
results in decreased up-regulation of TGFB signaling after MI (myocardial infarction) and protects against ventricular dysfunction
Susceptibility to atrioventricular septal defects
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascularatheromacardiac
may be a potential therapeutic target for attenuating the progression of ventricular remodeling in myocardial infarction
ANIMAL & CELL MODELS
  • fibulin-2 null mice had significantly better survival rate after MI compared to the wild-type mice as a result of less frequent cardiac rupture and preserved left ventricular function