Symbol
| FBLN2
| contributors: mct - updated : 05-12-2012
|
HGNC name
| fibulin 2
|
HGNC id
| 3601
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
in several breast cancer cell lines | constitutional
|  
|  
|  
|  
|
results in decreased up-regulation of TGFB signaling after MI (myocardial infarction) and protects against ventricular dysfunction | |
Susceptibility
|
to atrioventricular septal defects |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cardiovascular | atheroma | cardiac | |
may be a potential therapeutic target for attenuating the progression of ventricular remodeling in myocardial infarction |
| | | |
| fibulin-2 null mice had significantly better survival rate after MI compared to the wild-type mice as a result of less frequent cardiac rupture and preserved left ventricular function | |
|