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FLASH GENE
Symbol XPC contributors: mct - updated : 18-01-2016
HGNC name xeroderma pigmentosum, complementation group C
HGNC id 12816
ASSOCIATED DISORDERS
corresponding disease(s) XPC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in lung cancer cells, suppresses cell/tumor metastatic ability via repression of matrix metalloproteinase-1 (MMP1) transcription by TP53 (
Susceptibility
  • to squamous cell carcinoma of the head and neck
  • for breast, bladder, head and neck, and lung cancer
  • to cervical cancer risk
  • Variant & Polymorphism other
  • polyAT polymorphism
  • polymorphisms in XPC may represent low-penetrance susceptibility gene variants for breast, bladder, head and neck, and lung cancer
  • polymorphisms and haplotypes in XPC appear to influence cervical cancer risk and may modify risk attributable to tobacco usage
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS