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FLASH GENE
Symbol SON contributors: mct - updated : 18-10-2016
HGNC name SON DNA binding protein
HGNC id 11183
ASSOCIATED DISORDERS
corresponding disease(s) TOKIMS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in acute megakaryoblastic leukemia of Down syndrome
constitutional     --low  
leads to severe impairment of spindle pole separation, microtubule dynamics, and genome integrity
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • short SON overexpression is a marker indicating aberrant transcriptional initiation in leukemia
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    is a novel therapeutic molecular target for pancreatic cancer
    ANIMAL & CELL MODELS