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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

ORAI1

contributors: mct/npt/pgu - updated : 25-09-2015

HGNC name	ORAI calcium release-activated calcium modulator 1
HGNC id	25896

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD9

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         a single missense mutation in ORAI1 in some SCID patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast Both ATP2C22 and ORAI1 emerge as druggable targets of therapeutic potential in the treatment of some breast cancer subtypes neuromuscular myopathy   targeting Orai1 activity may be a promising therapeutic approach for the prevention and treatment of muscular dystrophy allergy asthm   strategies that target ORAI1 or the BPIFA1 deficiency in asthma may lead to novel therapies to treat this disease

ANIMAL & CELL MODELS