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FLASH GENE
Symbol TGM2 contributors: mct/pgu - updated : 16-05-2018
HGNC name transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
HGNC id 11778
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
overexpressed in ovarian cancer and promoting intraperitoneal metastasis
constitutional     --over  
overexpressed in cystic fibrosis and affecting NDPK function
constitutional     --over  
in neurons exposed to oxygen and glucose deprivation (OGD), and increased TGM2 expression protects neurons against OGD-induced cell death independent of its transamidating activity
Susceptibility
  • to schizophrenia
  • Variant & Polymorphism
    Candidate gene
    Marker
  • can serve as a biomarker for all grades of cervical dysplasia
  • may be used in diagnosis of pediatric mastocytosis, particularly systemic mastocytosis (SM)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of TGM2 may offer a novel strategy for anticancer therapy
    cancermetastases 
    inhibiting TGM2 may offer a novel therapeutic approach for managing and treatment of metastatic cancer
    cardiovascularaquired 
    is a potential therapeutic target for blocking neointima in blood vessels
    ANIMAL & CELL MODELS
  • glucose homeostasis in mice is Tgm2 independent