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FLASH GENE

Symbol

TGM2

contributors: mct/pgu - updated : 16-05-2018

HGNC name	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
HGNC id	11778

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in ovarian cancer and promoting intraperitoneal metastasis constitutional     --over   overexpressed in cystic fibrosis and affecting NDPK function constitutional     --over   in neurons exposed to oxygen and glucose deprivation (OGD), and increased TGM2 expression protects neurons against OGD-induced cell death independent of its transamidating activity

Susceptibility

to schizophrenia

Variant & Polymorphism

Candidate gene
Marker	can serve as a biomarker for all grades of cervical dysplasia
	may be used in diagnosis of pediatric mastocytosis, particularly systemic mastocytosis (SM)
Therapy target
	System Type Disorder Pubmed cancer     inhibition of TGM2 may offer a novel strategy for anticancer therapy cancer metastases   inhibiting TGM2 may offer a novel therapeutic approach for managing and treatment of metastatic cancer cardiovascular aquired   is a potential therapeutic target for blocking neointima in blood vessels

ANIMAL & CELL MODELS

glucose homeostasis in mice is Tgm2 independent