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FLASH GENE
Symbol CD47 contributors: mct/npt - updated : 13-06-2012
HGNC name CD47 molecule
HGNC id 1682
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
constitutively upregulated in myeloid leukemias
tumoral     --over  
in acute myeloid leukemia contributes to pathogenesis by inhibiting phagocytosis of these cells through the interaction of CD47 with SIRPA, and is associated with decreased overall survival
tumoral     --over  
in acute lymphoblastic leukemia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • important biomarker in breast cancer, and functions as a prognostic factor for disease-free survival
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    development of an anti-CD47 antibody therapy for treatment of acute lymphoblastic leukemia
    cancer  
    compelling target for therapeutic strategies that reduce its functional interaction with macrophage SIRPA and thus render these cancers susceptible to innate and adaptive immune system clearance
    neurologyacquired 
    may be a potential neurovascular target for stroke and brain injury
    cancer  
    blockade of its function leads to tumor cell phagocytosis and elimination. CD47 is therefore a validated target for cancer therapies
    ANIMAL & CELL MODELS
  • thymocyte numbers are reduced approximately twofold in CD47-/- mice