Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NFATC2 contributors: mct/npt/pgu - updated : 25-04-2012
HGNC name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
HGNC id 7776
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
not only protects the heart from pathological hypertrophy but also efficiently counteracts myocardial functional deterioration following biomechanical stress
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascularaquiredheart failure
targeting either NFATc2 activation or its immediate downstream target genes provide a suitable approach for future drug design to treat forms of pathological cardiac hypertrophy and heart failure
cancerdigestivepancreas
inactivation of oncogenic NFATc2 might be an attractive strategy in treatment of pancreatic cancer
ANIMAL & CELL MODELS