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FLASH GENE
Symbol PEBP1 contributors: mct/npt/pgu - updated : 20-06-2014
HGNC name phosphatidylethanolamine binding protein 1
HGNC id 8630
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
its inhibition results in increased cell proliferation by affecting spindle checkpoint, resulting in chromosomal aberrations and cancer progression
constitutional     --over  
in CEP290-associated photoreceptor degeneration
constitutional     --low  
increased the level of free RAF1 and thereby elevated the mitochondrial translocation of RAF1 during HBx-mediated hepatocarcinogenesis
tumoral     --low  
associated to poor prognosis in hepatocellular carcinoma related to hepatitis B infection
constitutional     --low  
might be responsible for dementia associated with high-altitude hypoxia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
PEBP1/GSK3 axis is both a potential therapeutic target and a prognosis-based predictor of cancer progression
cancer  
key metastasis suppressor and potential therapeutic agent
ANIMAL & CELL MODELS
  • Pebp1 deficiency renders the mice more susceptible to vesicular stomatitis virus (VSV) and herpes simplex virus (HSV) infections