Symbol
| PEBP1
| contributors: mct/npt/pgu - updated : 20-06-2014
|
HGNC name
| phosphatidylethanolamine binding protein 1
|
HGNC id
| 8630
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
its inhibition results in increased cell proliferation by affecting spindle checkpoint, resulting in chromosomal aberrations and cancer progression | constitutional
|  
|  
| --over
|  
|
in CEP290-associated photoreceptor degeneration | constitutional
|  
|  
| --low
|  
|
increased the level of free RAF1 and thereby elevated the mitochondrial translocation of RAF1 during HBx-mediated hepatocarcinogenesis | tumoral
|  
|  
| --low
|  
|
associated to poor prognosis in hepatocellular carcinoma related to hepatitis B infection | constitutional
|  
|  
| --low
|  
|
might be responsible for dementia associated with high-altitude hypoxia | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
PEBP1/GSK3 axis is both a potential therapeutic target and a prognosis-based predictor of cancer progression | cancer | | | |
key metastasis suppressor and potential therapeutic agent |
| | | |
| Pebp1 deficiency renders the mice more susceptible to vesicular stomatitis virus (VSV) and herpes simplex virus (HSV) infections |