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FLASH GENE
Symbol MTDH contributors: mct/npt/pgu - updated : 11-06-2015
HGNC name metadherin
HGNC id 29608
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic breast cancer
constitutional     --over  
in astrocytes infected with HIV-1 or treated with GP120 or tumor necrosis factor (TNF)-alph
tumoral     --over  
in breast and prostate tumors, melanoma and glioblastoma
tumoral     --other  
aberrant expression plays a dominant positive role in regulating oncogenic transformation and angiogenesis
tumoral     --over  
in more than 90p100 of brain tumors
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
may provide a viable target for directly suppressing the cancer phenotype
ANIMAL & CELL MODELS