Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CLCN3

contributors: mct - updated : 15-09-2021

HGNC name	chloride channel 3
HGNC id	2021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NEDHYBA , NEDSBA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   markedly reduces neointimal hyperplasia following vascular injury tumoral     --over   on the plasma membrane of human glioma cells where its activity is regulated through phosphorylation via Ca(2+)/calmodulin-dependent protein kinase II (CAMK2G) constitutional       loss of function causes severe neurodegeneration constitutional     --over   jn endometriosis, positively correlated with endometrioma size

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   target for the prevention of inflammatory and proliferative vascular diseases cancer angiogenesis   target for the prevention of inflammatory and proliferative vascular diseases

ANIMAL & CELL MODELS

	ClC-3-null mice exhibited a reduction in neointimal area of the carotid artery 28 days after injury
	Clcn3-/- mice display severe neurodegeneration, leading to an almost complete loss of the hippocampus within a few months of life and to blindness from an early complete loss of photoreceptors