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FLASH GENE

Symbol

ATAD2

contributors: mct - updated : 05-03-2011

HGNC name	ATPase family, AAA domain containing 2
HGNC id	30123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   up-regulated in breast, uterus, colon, ovary, and stomach tumors tumoral     --over   in several cancer, and its high expression is a strong predictor of rapid mortality in lung and breast cancers tumoral     --over   in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     intrinsic properties of its two domains, AAA-ATPase and bromodomain, could provide a basis for the development of therapeutic strategies specifically targeting ATAD2 in cancer cancer reproductive breast prognostic marker and a therapeutic target for triple-negative cancers

ANIMAL & CELL MODELS