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FLASH GENE
Symbol ALCAM contributors: mct/npt - updated : 24-08-2016
HGNC name activated leukocyte cell adhesion molecule
HGNC id 400
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
ALCAM-ALCAM interactions protects breast cancer cells against apoptosis and autophagy
tumoral     --low  
in breast cancer tissue are known to correlate with poor prognosis, and patients who develop skeletal metastasis tend to have the lowest levels of ALCAM transcripts in their breast cancers (Davies 2008)
tumoral     --over  
in breast cancer and high membranous expression of ALCAM probably resulted in weakened adherent ability and metastasis
tumoral     --over  
in papillary and medullary thyroid cancer
Susceptibility
Variant & Polymorphism
Candidate gene novel serum biomarker in human pancreatic tumors which is associated with cell adhesion, growth and chemoresistance (Hong 2010)
Marker
Therapy target
  • therapeutic potential for a secreted variant (sALCAM)
  • SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential novel breast cancer indicator and therapeutic target
    ANIMAL & CELL MODELS
  • CD166(-/-) mice exhibited a modest increase in trabecular bone fraction (42p100), and increases in osteoid deposition (72p100), Osteoblast number (60p100), and bone formation rate (152p100)