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FLASH GENE
Symbol GFPT1 contributors: mct/npt/pgu - updated : 02-02-2022
HGNC name glutamine-fructose-6-phosphate transaminase 1
HGNC id 4241
ASSOCIATED DISORDERS
corresponding disease(s) CMSTA1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in pancreatic cancer samples compared to peri-tumor tissues, and positively associated with lymph node metastasis, pTNM stage and shorter overall survival (OS)
Susceptibility
  • to insulin resistance of non-insulin dependent diabetes mellitus (minor role)
  • to diabetic nephropathy
  • Variant & Polymorphism SNP
  • 2 SNP increasing the risk of diabetic nephropathy
  • Candidate gene
    Marker
  • high GFPT1 expression is identified as an independent predictor of adverse clinical outcome in our small number of pancreatic cancer patients
  • Therapy target
    ANIMAL & CELL MODELS