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FLASH GENE
Symbol SLC9C1 contributors: mct - updated : 19-02-2018
HGNC name solute carrier family 9 member C1
HGNC id 31401
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
linked to the pathogenesis of several diseases, including essential hypertension, diabetes, congenital secretory diarrhea, tissue damage caused by ischemia/reperfusion and oncogenic transformation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabete  
development of drugs that modulate the activity of SLC9C1 could, in the future, become new strategies for the treatment of diabetes or its chronic complications.
ANIMAL & CELL MODELS
  • disruption of the sNHE gene in mice resulted in absolute male infertility associated with a complete loss of sperm motility