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FLASH GENE
Symbol ZNF521 contributors: mct - updated : 18-11-2009
HGNC name zinc finger protein 521
HGNC id 24605
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
acute myelogenous leukemia
tumoral     --over  
in CD34+ progenitors and hematopoietic malignancies
tumoral     --over  
in most acute myelogenous leukaemias and is particularly high in those with rearrangements of the MLL gene, where EHZF may contribute to the leukaemic phenotype
Susceptibility
Variant & Polymorphism
Candidate gene
  • is a cooperative gene for TCF3-HLF to develop acute B-lineage leukemia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS