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FLASH GENE
Symbol TNS4 contributors: mct/ - updated : 28-08-2015
HGNC name tensin 4
HGNC id 24352
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
or nul in prostate cancers and prostate cancer cell lines
tumoral     --over  
in 70 p100 of pancreatic cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • its expression is of prognostic significance in colorectal cancer, delineating a TNS4-ILK pathway controlling cell motility and possibly promoting metastasis
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS