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FLASH GENE
Symbol P2RX2 contributors: mct - updated : 28-08-2014
HGNC name purinergic receptor P2X, ligand-gated ion channel, 2
HGNC id 15459
ASSOCIATED DISORDERS
corresponding disease(s) DFNA41
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • P2X-knockout mice show greatly reduced behavioral responses to sweeteners, glutamate, and bitter substances
  • P2RX2-null mice developed severe progressive hearing loss, and their early exposure to continuous moderate noise led to high-frequency hearing loss as young adults