Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DDIT4

contributors: mct/npt/pgu - updated : 20-03-2015

HGNC name	DNA-damage-inducible transcript 4
HGNC id	24944

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer constitutional     --over   during ER stress through a mechanism involving activation of EIF2AK3, phosphorylation of EIF2A, and increased ATF4 expression constitutional     --over   in Parkinson disease substantia nigral neurons that may mediate their degeneration and death constitutional     --over   in osteoblast cell line (hFOB) cells after gamma irradiation tumoral     --over   in breast lesion patients as compared with normal controls

Susceptibility

to Alzheimer's disease

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   may thus be a potential therapeutic protein for inhibiting lung metastasis and invasion cancer reproductive prostate target for therapeutic intervention in prostate cancer cancer     apoptotic effect of FAS inhibition in tumor cells to up-regulation of DDIT4), a stress-response gene that negatively regulates the MTOR pathway neurology neurodegenerative Parkinson/dementia Parkinsonism with its signaling cascade may be novel potential therapeutic targets for Parkinson disease

ANIMAL & CELL MODELS