Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DDIT4 contributors: mct/npt/pgu - updated : 20-03-2015
HGNC name DNA-damage-inducible transcript 4
HGNC id 24944
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate cancer
constitutional     --over  
during ER stress through a mechanism involving activation of EIF2AK3, phosphorylation of EIF2A, and increased ATF4 expression
constitutional     --over  
in Parkinson disease substantia nigral neurons that may mediate their degeneration and death
constitutional     --over  
in osteoblast cell line (hFOB) cells after gamma irradiation
tumoral     --over  
in breast lesion patients as compared with normal controls
Susceptibility to Alzheimer's disease
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerlung 
may thus be a potential therapeutic protein for inhibiting lung metastasis and invasion
cancerreproductiveprostate
target for therapeutic intervention in prostate cancer
cancer  
apoptotic effect of FAS inhibition in tumor cells to up-regulation of DDIT4), a stress-response gene that negatively regulates the MTOR pathway
neurologyneurodegenerativeParkinson/dementia Parkinsonism
with its signaling cascade may be novel potential therapeutic targets for Parkinson disease
ANIMAL & CELL MODELS