Symbol
| TPPP
| contributors: mct/pgu - updated : 29-06-2017
|
HGNC name
| tubulin polymerization promoting protein
|
HGNC id
| 24164
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
| amplification
|  
|  
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in early stages of non-small cell lung cancer | tumoral
|  
| amplification
|  
|  
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in high-grade bladder cancers | constitutional
|  
|  
| --over
|  
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in the cerebrospinal fluid (CSF) of MS patients, and its level is significantly higher than in the case of non-MS patients | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| loss of TPPP-positive oligodendrocytes in demyelinated lesions in the brain of Multiple sclerosis (MS) patients could be a biomarker for MS | |
TPPP in human CSF can become diagnostic marker for MS | Therapy target
| | |
| ringer-null mutants show cell misplacement, and errors in axonal extension and targeting |