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FLASH GENE
Symbol TPPP contributors: mct/pgu - updated : 29-06-2017
HGNC name tubulin polymerization promoting protein
HGNC id 24164
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in early stages of non-small cell lung cancer
tumoral   amplification    
in high-grade bladder cancers
constitutional     --over  
in the cerebrospinal fluid (CSF) of MS patients, and its level is significantly higher than in the case of non-MS patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • loss of TPPP-positive oligodendrocytes in demyelinated lesions in the brain of Multiple sclerosis (MS) patients could be a biomarker for MS
  • TPPP in human CSF can become diagnostic marker for MS
  • Therapy target
    ANIMAL & CELL MODELS
  • ringer-null mutants show cell misplacement, and errors in axonal extension and targeting