Symbol
| IRF8
| contributors: mct/npt/pgu - updated : 11-06-2016
|
HGNC name
| interferon regulatory factor 8
|
HGNC id
| 5358
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
in AML and chronic myeloid leukemia during blast crisis (CML-BC), and its deficiency may be functionally important for accumulation of chromosomal abnormalities during disease progression in these myeloid malignancies | tumoral
|  
|  
| --over
|  
|
IRF8 and TNFSF13 expression was significantly higher in lymphomas with IGH rearrangements targeting these loci | |
Susceptibility
|
to systemic lupus erythematosus |
Variant & Polymorphism
SNP
| rs11648084 and rs11644034 associated to systemic lupus erythematosus |
|
|
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
immunology | autoimmune | Lupus | |
IRF8 may provide important targets for therapeutic intervention in human lupus |
| | | |
| Irf8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast crisis, thereby resembling human chronic myelogeneous leukemia (CML) | |
|