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FLASH GENE
Symbol IRF8 contributors: mct/npt/pgu - updated : 11-06-2016
HGNC name interferon regulatory factor 8
HGNC id 5358
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in AML and chronic myeloid leukemia during blast crisis (CML-BC), and its deficiency may be functionally important for accumulation of chromosomal abnormalities during disease progression in these myeloid malignancies
tumoral     --over  
IRF8 and TNFSF13 expression was significantly higher in lymphomas with IGH rearrangements targeting these loci
Susceptibility to systemic lupus erythematosus
Variant & Polymorphism SNP
  • rs11648084 and rs11644034 associated to systemic lupus erythematosus
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    IRF8 may provide important targets for therapeutic intervention in human lupus
    ANIMAL & CELL MODELS
  • Irf8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast crisis, thereby resembling human chronic myelogeneous leukemia (CML)