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FLASH GENE
Symbol JMJD1C contributors: mct - updated : 06-01-2016
HGNC name jumonji domain containing 1C
HGNC id 12313
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in breast cancer
constitutional germinal mutation      
contribute to the development of Rett syndrome and intellectual disability
Susceptibility
Variant & Polymorphism other
  • heterozygous variants in RREB1, when combined with the 22q11.2 deletion, could affect embryonic development or heart formation in humans
  • Candidate gene for autism
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target in leukemia
    ANIMAL & CELL MODELS
  • Jmjd1c-deficient males became infertile due to the progressive reduction of germ cells after 3 mo of age