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FLASH GENE
Symbol RAB1A contributors: mct - updated : 06-02-2024
HGNC name RAB1A, member RAS oncogene family
HGNC id 9758
ASSOCIATED DISORDERS
corresponding disease(s) NDDSM
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
significantly upregulated in CRC tissues and increased RAB1A expression correlated with tumor size, lymph node metastasis (LNM) and tumor-node-metastasis
tumoral     --over  
overexpressed in CRC tissues compared with matched noncancerous tissues
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • RAB1A is an important diagnostic marker for Colorectal cancer (CRC), and RAB1A can be used as a valuable biomarker for prognosis as well as peritoneal metastasis in CRC patients (PMIS: 30058685)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may prove to be clinically useful for developing a new therapeutic target of CRC treatment
    ANIMAL & CELL MODELS
  • Rab1a was found to be highly expressed in the small intestine of both adult mice and embryos, although its expression levels were low in the brains of embryos, and disruption of the Rab1a gene causes embryonic lethality