Symbol
| RAB1A
| contributors: mct - updated : 06-02-2024
|
HGNC name
| RAB1A, member RAS oncogene family
|
HGNC id
| 9758
|
corresponding disease(s)
|
NDDSM
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
significantly upregulated in CRC tissues and increased RAB1A expression correlated with tumor size, lymph node metastasis (LNM) and tumor-node-metastasis | tumoral
|  
|  
| --over
|  
|
overexpressed in CRC tissues compared with matched noncancerous tissues | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| RAB1A is an important diagnostic marker for Colorectal cancer (CRC), and RAB1A can be used as a valuable biomarker for prognosis as well as peritoneal metastasis in CRC patients (PMIS: 30058685) | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | colon | |
may prove to be clinically useful for developing a new therapeutic target of CRC treatment |
| | |
| Rab1a was found to be highly expressed in the small intestine of both adult mice and embryos, although its expression levels were low in the brains of embryos, and disruption of the Rab1a gene causes embryonic lethality |