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FLASH GENE
Symbol CD200R1 contributors: mct - updated : 01-02-2012
HGNC name CD200 receptor 1
HGNC id 24235
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
enhanced expression of CD200 and CD200R1 in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy
constitutional     --other  
aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity
Susceptibility
Variant & Polymorphism
Candidate gene it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativeParkinson/dementia Parkinsonism
it is very promising to regulate microglia activation in Parkinson disease via targeting CD200-CD200R1 signaling pathways
cancerskin 
CD200 and CD200R1 are potential therapeutic target for metastatic melanoma
ANIMAL & CELL MODELS