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FLASH GENE
Symbol SEPTIN11 contributors: mct - updated : 29-08-2019
HGNC name septin 11
HGNC id 25589
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with MLL in t(4;11)(q21;q23)in chronic neutrophilic leukemia and in lymphoblastic leukemia
tumoral   LOH    
may play an important role in hepatocellular carcinoma development and progression, and is associated with a significantly lower survival rate
tumoral fusion      
SEPTIN11/KMT2A in acute lymphoblastic leukemia (ALL)
constitutional        
impaired insulin signalling and insulin-induced lipid accumulation in adipocytes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS