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FLASH GENE
Symbol OSMR contributors: mct - updated : 11-03-2020
HGNC name oncostatin M receptor
HGNC id 8507
ASSOCIATED DISORDERS
corresponding disease(s) FPLCA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional        
silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of chronic autoimmune urticaria (CAU)
tumoral     --over  
in advanced cervical squamous cell carcinoma (SCC)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may serve as a biomarker candidate gene to predict prognosis of bladder cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • mice, lacking the OSM receptor (Osmr) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance