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FLASH GENE
Symbol PSRC1 contributors: mct/npt - updated : 01-12-2009
HGNC name proline/serine-rich coiled-coil 1
HGNC id 24472
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
lung cancer
constitutional     --low  
during DNA damage
tumoral     --over  
frequently in malignant peripheral nerve sheath tumor cells
constitutional     --low  
causes a hyper-stabilization of spindle MT, a loss of inter-kinetochore tension, and a defect in chromosome congression, leading to unaligned chromosomes at metaphase
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS