Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CRTC2 contributors: mct - updated : 13-04-2015
HGNC name CREB regulated transcription coactivator 2
HGNC id 27301
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
hepatic CRTC2 activity is elevated in obesity
constitutional       gain of function
hyperactivation of CRTC2 would exacerbate insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol (DAG) synthesis
constitutional     --other  
dysregulation of TORC2 would further exaggerate insulin resistance and promote type 2 diabetes in a LIPIN1-dependent manner
tumoral     --over  
may play an important role in the development and hereditary of in non-small cell lung cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
miscelleaneoushypertension 
pharmacological manipulation of CRTC1/2 signalling may provide novel therapies for Na(+)-sensitive hypertension
diabetetype 2 
small molecules that attenuate the CREB-CRTC2 pathway may provide therapeutic benefit to individuals with type 2 diabetes
cancerhemopathy 
therapeutic target in multiple myeloma
cancer  
cotranslational functions of CRTC2 could be tapped for therapeutics against cancer
neurologyneurodegenerative 
cotranslational functions of CRTC2 could be tapped for therapeutics paricularly against diseases caused by protein misprocessing, such as neurodegenerative and aging-related disorders
cancerskin 
disrupting the CRTC2-ribosome interaction may be a useful strategy in the treatment of melanomas, colon carcinomas, and possibly other cancers
ANIMAL & CELL MODELS
in Crtc2 (-/-) mice lowered circulating blood glucose concentrations and improved insulin sensitivity in the context of diet-induced obesity