System | Type | Disorder | Pubmed |
miscelleaneous | hypertension | | |
pharmacological manipulation of CRTC1/2 signalling may provide novel therapies for Na(+)-sensitive hypertension |
diabete | type 2 | | |
small molecules that attenuate the CREB-CRTC2 pathway may provide therapeutic benefit to individuals with type 2 diabetes |
cancer | hemopathy | | |
therapeutic target in multiple myeloma |
cancer | | | |
cotranslational functions of CRTC2 could be tapped for therapeutics against cancer |
neurology | neurodegenerative | | |
cotranslational functions of CRTC2 could be tapped for therapeutics paricularly against diseases caused by protein misprocessing, such as neurodegenerative and aging-related disorders |
cancer | skin | | |
disrupting the CRTC2-ribosome interaction may be a useful strategy in the treatment of melanomas, colon carcinomas, and possibly other cancers |