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FLASH GENE
Symbol KDM4B contributors: mct - updated : 23-12-2020
HGNC name lysine (K)-specific demethylase 4B
HGNC id 29136
ASSOCIATED DISORDERS
corresponding disease(s) GDDLM
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor
tumoral     --over  
in colorectal cancer (CRC) tissues
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveprostate
is a viable therapeutic target in Prostate carcinoma
cancerreproductivebreast
potential therapeutic target in breast cancer
cancerreproductiveprostate
KDM4B may be served as a potential target for Castration-resistant prostate cancer (CRPC) therapy
cancerdigestivecolon
potential therapeutic cancer target in Colorectal cancer (
osteoarticularboneostéoporosis
KDM4B may present as therapeutic targets for controlling mesenchymal stem/stromal cells (MSCs) fate choices and lead to clues for new treatment in metabolic bone diseases such as osteoporosis
ANIMAL & CELL MODELS