Symbol
| OSTN
| contributors: mct/npt - updated : 10-01-2024
|
HGNC name
| osteocrin
|
HGNC id
| 29961
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
induces insulin resistance in type 2 diabetes | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cardiovascular | aquired | heart failure | |
augmentation of OSTN might serve as therapeutic strategy | diabete | type 1 | | |
is a promising therapeutic target to treat diabetic cardiomyopathy (DCM) | miscelleaneous | hypertension | | |
is a novel target for treatment of hypertension |
| | | |
| continuous infusion of the peptide Ostn, an endogenous ligand of Npr3 secreted by bone and muscle cells, lowered blood pressure in wild-type mice, suggesting that endogenous natriuretic peptides play major roles in the regulation of blood pressure |