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FLASH GENE
Symbol OSTN contributors: mct/npt - updated : 10-01-2024
HGNC name osteocrin
HGNC id 29961
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
induces insulin resistance in type 2 diabetes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascularaquiredheart failure
augmentation of OSTN might serve as therapeutic strategy
diabetetype 1 
is a promising therapeutic target to treat diabetic cardiomyopathy (DCM)
miscelleaneoushypertension 
is a novel target for treatment of hypertension
ANIMAL & CELL MODELS
  • continuous infusion of the peptide Ostn, an endogenous ligand of Npr3 secreted by bone and muscle cells, lowered blood pressure in wild-type mice, suggesting that endogenous natriuretic peptides play major roles in the regulation of blood pressure