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FLASH GENE
Symbol NAALADL2 contributors: mct/npt - updated : 15-10-2020
HGNC name N-acetylated alpha-linked acidic dipeptidase-like 2
HGNC id 23219
ASSOCIATED DISORDERS
corresponding disease(s) DUP3QD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
significantly decreased in the tissues of patients with inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) compared to those in control tissues
tumoral     --over  
in colon and prostate tumours when compared with benign tissue
Susceptibility
  • to Kawasaki disease (KD)
  • to intestinal Behçet's disease
  • Variant & Polymorphism SNP
  • rs17531088 significantly associated to KS (Burgner 2009)
  • NAALADL2 gene locus (rs3914501),is associated with intestinal Behçet's disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS