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FLASH GENE
Symbol ZHX2 contributors: mct/npt/pgu - updated : 12-07-2015
HGNC name zinc fingers and homeoboxes 2
HGNC id 18513
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma
tumoral   translocation    
aberration with recurrent breakpoints in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which activate PDE5A and repress ZHX2, deregulating apoptosis, differentiation, and STAT1-signaling in HL cells
tumoral     --low  
in myeloma patients, compared with peripheral blood lymphocytes
tumoral     --low  
is responsible for GPC3 reactivation in hepatocellular carcinoma (HCC)
tumoral     --over  
in clear cell Renal cell carcinoma (RCC)
tumoral     --over  
high mRNA levels of ZHX2 and ZHX3 correlated with better overall survival in patients with breast cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerurinary 
is a potential therapeutic target for Clear Cell Renal Cell Carcinoma (PMID: 30026228)
ANIMAL & CELL MODELS
  • a mutation of Zhx2 carried in BALB/cJ mice is responsible in large part for its relative resistance to atherosclerosis