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FLASH GENE
Symbol ACKR3 contributors: mct - updated : 07-04-2015
HGNC name atypical chemokine receptor 3
HGNC id 23692
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with HMGA2 in t(2;12)(q35;q13)in lipomas
tumoral     --over  
highly expressed in breast, lung and prostate cancers (Van Rechem 2009)
tumoral        
expression of CXCR7 increase as the tumors become more aggressive in prostate cancers (Wang 2008)
tumoral        
higher expression of CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer (Iwakiri 2009)
tumoral     --over  
in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and ACKR3 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target blocking of CXCR7 can be useful for therapeutic interference with CXCR4-mediated activation of integrins (Hartmann 2008)
SystemTypeDisorderPubmed
cancerreproductivebreast
inhibition of NFKB1 signaling could be used in association with hormonotherapies to inhibit ACKR3 expression in breast cancer cells, thus limiting the proliferative and the pro-migrative effects of this receptor
miscelleaneoushypertension 
CXCR4 and ACKR3 as new pharmacological targets to control vasoreactivity and blood pressure
ANIMAL & CELL MODELS