Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRP1 contributors: mct/pgu - updated : 14-03-2017
HGNC name low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
HGNC id 6692
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
may be associated with abdominal aortic aneurysm progression
Susceptibility
  • putative susceptibility factor for Alzheimer disease (see AD5), not confirmed
  • to abdominal aortic aneurysm
  • to sporadic thoracic aortic dissection (STAD)
  • Variant & Polymorphism SNP
  • rs1466535, T allele which might disrupt a binding site for SREBF1, located within intron 1 of LRP1 significantly associated to abdominal aortic aneurysm
  • SNPs in LRP1 were identified to be significantly associated with STAD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorial  
    target for therapeutic intervention in proliferative vitreoretinopathy
    obesity  
    pharmacological modulation of LRP1 activity might emerge as a novel rational approach for treating diabetes and obesity, as well as atherosclerosis
    diabete  
    pharmacological modulation of LRP1 activity might emerge as a novel rational approach for treating diabetes and obesity, as well as atherosclerosis
    neurologyacquired 
    LRP1 agonists promote regeneration after spinal cord injury
    ANIMAL & CELL MODELS
  • mice with conditional loss of LRP1 in post-mitotic neurons exhibit alterations in brain lipid metabolism, synapse loss, and neurodegeneration