Symbol
| LRP1
| contributors: mct/pgu - updated : 14-03-2017
|
HGNC name
| low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
|
HGNC id
| 6692
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
may be associated with abdominal aortic aneurysm progression | |
Susceptibility
|
putative susceptibility factor for Alzheimer disease (see AD5), not confirmed to abdominal aortic aneurysm to sporadic thoracic aortic dissection (STAD) |
Variant & Polymorphism
SNP
| rs1466535, T allele which might disrupt a binding site for SREBF1, located within intron 1 of LRP1 significantly associated to abdominal aortic aneurysm |
|
SNPs in LRP1 were identified to be significantly associated with STAD |
|
|
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
neurosensorial | | | |
target for therapeutic intervention in proliferative vitreoretinopathy
| obesity | | | |
pharmacological modulation of LRP1 activity might emerge as a novel rational approach for treating diabetes and obesity, as well as atherosclerosis | diabete | | | |
pharmacological modulation of LRP1 activity might emerge as a novel rational approach for treating diabetes and obesity, as well as atherosclerosis | neurology | acquired | | |
LRP1 agonists promote regeneration after spinal cord injury |
| | | |
| mice with conditional loss of LRP1 in post-mitotic neurons exhibit alterations in brain lipid metabolism, synapse loss, and neurodegeneration |