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FLASH GENE
Symbol DOCK5 contributors: mct - updated : 11-01-2017
HGNC name dedicator of cytokinesis 5
HGNC id 23476
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
osteoarticularboneostéoporosis
pharmacological inhibition of DOCK5 is a novel therapeutic route for fighting osteolytic diseases while preserving bone formation
ANIMAL & CELL MODELS
  • adult Dock5(-/-) mice have increased trabecular bone mass, and also have normal hypertrophic cartilage and cartilage trabecular network
  • Dock5-deficient mice exhibit resistance to systemic and cutaneous anaphylaxis