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FLASH GENE
Symbol BIN1 contributors: mct/pgu - updated : 23-01-2014
HGNC name bridging integrator 1
HGNC id 1052
ASSOCIATED DISORDERS
corresponding disease(s) CNM3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
prostate and breast carcinomas
tumoral     --low  
in primary hepatocellular carcinoma tumor tissues
Susceptibility to familial late-onset Alzheimer disease
Variant & Polymorphism SNP SNPs in BIN1, in association with APOE epsilon4 homozygotes associated to familial late-onset Alzheimer disease
Candidate gene
Marker
  • could serve as a marker for metastatic potential and chemosensitivity (
  • novel prognostic marker in hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    novel therapeutic target for IBD treatment
    ANIMAL & CELL MODELS
  • Bin1 splicing alteration in mice is sufficient to promote T tubule alterations and muscle weakness, a predominant feature of myotonic dystrophy