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FLASH GENE
Symbol AMBN contributors: mct/pgu - updated : 18-08-2021
HGNC name ameloblastin (enamel matrix protein)
HGNC id 452
ASSOCIATED DISORDERS
corresponding disease(s) AI1F
Susceptibility
  • to dental caries
  • to Molar-Incisor Hypomineralization
  • Variant & Polymorphism other
  • rs7439186 in AMBN is involved in gene-by-fluoride interactions, in dental caries
  • rs34367704 associated with Molar-Incisor Hypomineralization
  • Candidate gene
  • candidate gene for dentinogenesis imperfecta and/or autosomal dominant amylogenesis imperfecta (AIH2)
  • defects in patients with ameloblastomas
  • gene alterations may be relevant tot he pathogenesis of calcifying epithelial odontogenic tumor
  • Marker
    Therapy target
    ANIMAL & CELL MODELS