Symbol
| NEIL2
| contributors: mct/npt - updated : 18-12-2014
|
HGNC name
| nei like 2 (E. coli)
|
HGNC id
| 18956
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
| deletion
|  
|  
|
in congenital heart disease | |
Susceptibility
|
to familial colorectal cancer to lung cancer development |
Variant & Polymorphism
other
| missense variants increasing the risk of colorectal cancer |
|
decreased DNA repair capacity of the R257L variant can induce mutations that lead to lung cancer development |
|
|
Candidate gene
| polymorphisms of the NEIL2 gene may be markers for risk and progression of squamous cell carcinoma of the oral cavity and oropharynx, particularly in patients with oropharyngeal cancer (Zhai 2008) |
Marker
Therapy target
| | |