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FLASH GENE

Symbol

NDFIP1

contributors: mct/ - updated : 21-09-2018

HGNC name	Nedd4 family interacting protein 1
HGNC id	17592

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   with NEDD4 proteins are up-regulated in stressed neurons during brain injury constitutional     --over   in cortical neurons following traumatic brain injury, and this over-expression is protective against neuronal apoptosis constitutional     --over   in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mice lacking Ndfip1 have increased numbers of Th17 cells, and this increase is cell intrinsic
	Th2 inflammation, such as that observed in Ndfip1(-/-) mice, can increase Th17 differentiation by recruiting Il6-producing eosinophils into secondary lymphoid organs and tissues