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FLASH GENE
Symbol AFF3 contributors: mct/npt - updated : 26-05-2021
HGNC name AF4/FMR2 family, member 3
HGNC id 6473
ASSOCIATED DISORDERS
corresponding disease(s) KINSSHIP
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with MLL in t(2;11)(p15;p14) in ALL
tumoral fusion      
5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma (Impera 2008)
constitutional   deletion    
interstitial microdeletion in Nievergelt sndrome (Steichen-Gersdorf 2008)
tumoral fusion      
with RUNX1, partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) (Chinen 2008)
Susceptibility to rheumatoid arthritis (RA)
Variant & Polymorphism other association of the AFF3 locus with RA susceptibility (Barton 2009)
Candidate gene for specific changes of the tibia
Marker
Therapy target
ANIMAL & CELL MODELS