Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLD3 contributors: mct - updated : 11-04-2022
HGNC name phospholipase D3
HGNC id 17158
ASSOCIATED DISORDERS
corresponding disease(s) SCA46
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in Alzheimer disease (AD) brains, which was negatively correlated with amyloid precursor protein (APP) and amyloid-beta (Abeta) levels
constitutional     --low  
in the human hippocampus in AD cases compared to controls
Susceptibility to Alzheimer's disease (AD)
Variant & Polymorphism other
  • coding variant confers increased risk for the development of Alzheimer's disease (AD)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    targeting PLD3 may provide new opportunities for AD therapeutic strategies
    ANIMAL & CELL MODELS