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FLASH GENE
Symbol NFE2L2 contributors: mct/npt/pgu/shn - updated : 02-07-2016
HGNC name nuclear factor (erythroid-derived 2)-like 2
HGNC id 7782
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in lung cancers
tumoral       gain of function
constitutive NFE2L2 activation might cause drug resistance in tumours
constitutional     --low  
resulted in decreased HDAC2 in lung, and increased inflammatory lung response which was not reversed by steroid
Susceptibility to acute lung injury
Variant & Polymorphism SNP increasing the risk of acute lung injury
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
inhibition of NFE2L2 could be used to enhance chemotherapeutic sensitivity
respiratorylung 
NFE22 targeting might provide clinical benefit by reducing both oxidative stress and inflammation in COPD (chronic obstructive pulmonary disease)
digestive  
Nrf2 activation by synthetic triterpenoids is a promising candidate target to protect the gastrointestinal tract against acute ionizing radiation
osteoarticularboneothers
KEAP1-NFE2L2 axis may be a therapeutic target for the treatment of bone destructive disease
reproductionfertility 
therapeutic intervention targeting PARK7 for the treatment of asthenozoospermia
ANIMAL & CELL MODELS
  • Nrf2(-/-) mice were highly susceptible to N-acetyl-p-aminophenol treatment and died of liver failure
  • mice targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged erythrocytes .
  • Nrf2-deficient mice show decolourization of the incisors
  • Disruption of the Nrf2 gene in mice led to earlier-onset and more extensive cigarette smoke-induced emphysema
  • Disruption of Nrf2 dramatically increased the mortality of mice in response to endotoxin- and cecal ligation and puncture-induced septic shock
  • Nrf2-deficient mice developed tumors more readily in response to carcinogen exposure and caloric exposure was ineffective in suppressing tumors in the KO mice
  • expression levels of NRF1 is significantly decreased in both Alzheimer's disease hippocampal tissues and AD-causing amyloid precursor protein mutant cells
  • Nrf2-null mice develop diffuse white matter injury without overt loss of neurons