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FLASH GENE

Symbol

PNLIPRP2

contributors: mct - updated : 02-05-2011

HGNC name	pancreatic lipase-related protein 2
HGNC id	9157

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       W340X mutation may contribute to aberrant folding, may have other cellular effects along with the general loss of lipolytic activity, and may increase susceptibility of pancreatic exocrine cells to other metabolic stressors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Plrp2-deficient mouse pups have significant fat maldigestion that disappears coincident with the expression of Pnipl thereby confirming the important role of Plrp2 in fat digestion in the newborn mouse