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FLASH GENE
Symbol DPPA3 contributors: mct - updated : 13-07-2017
HGNC name developmental pluripotency associated 3
HGNC id 19199
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional        
loss of maternal DPPA3 results in widespread transcriptional mis-regulation and a partial failure of maternal-to-zygotic transition (MZT)
tumoral     --over  
enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes
constitutional       loss of function
led to developmental arrest at the preimplantation stage, accompanied by frequent chromosome segregation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Stella-null embryos exhibited impaired CF and reduced expression of the reverse strand of major satellite repeats