Symbol
| DPPA3
| contributors: mct - updated : 13-07-2017
|
HGNC name
| developmental pluripotency associated 3
|
HGNC id
| 19199
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
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loss of maternal DPPA3 results in widespread transcriptional mis-regulation and a partial failure of maternal-to-zygotic transition (MZT) | tumoral
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| --over
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enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes | constitutional
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| loss of function
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led to developmental arrest at the preimplantation stage, accompanied by frequent chromosome segregation | |
Variant & Polymorphism
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Candidate gene
Marker
Therapy target
| | | |
| Stella-null embryos exhibited impaired CF and reduced expression of the reverse strand of major satellite repeats |